Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication.

ABSTRACT: Toxoplasma gondii possesses an armada of secreted virulent factors that enable parasite invasion and survival into host cells. These factors are contained in specific secretory organelles, the rhoptries, micronemes and dense granules that release their content upon host cell recognition. Dense granules are secreted in a constitutive manner during parasite replication and play a crucial role in modulating host metabolic and immune responses. While the molecular mechanisms triggering rhoptry and microneme release upon host cell adhesion have been well studied, constitutive secretion remains a poorly explored aspect of T. gondii vesicular trafficking. Here, we investigated the role of the small GTPase Rab11A, a known regulator of exocytosis in eukaryotic cells. Our data revealed an essential

SUBMITTER: Venugopal K 

PROVIDER: S-EPMC7255593 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature