Extracellular vesicular microRNAs as potential biomarker for early detection of doxorubicin-induced cardiotoxicity.

ABSTRACT:

Background

Long-term use of doxorubicin (DOX) is limited by cumulative dose-dependent cardiotoxicity.

Objectives

Identify plasma extracellular vesicle (EV)-associated microRNAs (miRNAs) as a biomarker for cardiotoxicity in dogs by correlating changes with cardiac troponin I (cTnI) concentrations and, echocardiographic and histologic findings.

Animals

Prospective study of 9 client-owned dogs diagnosed with sarcoma and receiving DOX single-agent chemotherapy (total of 5 DOX treatments). Dogs with clinically relevant metastatic disease, preexisting heart disease, or breeds predisposed to cardiomyopathy were excluded.

Methods

Serum concentration of cTnI was monitored before each treatment and 1 month after the treatment completion. Echocardiography was performed be

SUBMITTER: Beaumier A 

PROVIDER: S-EPMC7255649 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature