Effects of oral administration of 5 immunosuppressive agents on activated T-cell cytokine expression in healthy dogs.

ABSTRACT:

Background

Dogs are often adminstered >1 immunosuppressive medication when treating immune-mediated diseases, and determining whether these different medications affect IL-2 expression would be useful when performing pharmacodynamic monitoring during cyclosporine therapy.

Hypothesis/objectives

To determine the effects of 5 medications (prednisone, cyclosporine, azathioprine, mycophenolate mofetil, and leflunomide) on activated T-cell expression of the cytokines IL-2 and interferon-gamma (IFN-γ).

Animals

Eight healthy dogs.

Methods

Randomized, cross-over study comparing values before and after treatment, and comparing values after treatment among drugs. Dogs were administered each drug at standard oral doses for 1 week, with a washout of at least 21 days. Activa

SUBMITTER: Archer TM 

PROVIDER: S-EPMC7255661 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature