Urine hemojuvelin in cats with naturally occurring kidney disease.

ABSTRACT:

Background

Soluble-type hemojuvelin in serum and urine has been shown to be a biomarker in humans for chronic kidney disease (CKD) and acute kidney injury (AKI). No similar research has been conducted on cats.

Objective

Urine hemojuvelin (u-hemojuvelin) can be used as a clinical indicator for cats with various renal diseases.

Animals

Eighteen healthy cats, 10 cats with AKI, 21 cats with acute-on-chronic kidney injury (ACKI), and 45 cats with CKD were enrolled.

Methods

The expression profile of u-hemojuvelin was assessed by Western blot analysis, whereas the u-hemojuvelin concentration was measured using an in-house sandwich ELISA. Each cat's u-hemojuvelin-to-creatinine ratio (UHCR) also was determined.

Results

Significant differences were found in both u

SUBMITTER: Jing H 

PROVIDER: S-EPMC7255673 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature