Twenty-four-hour subjective and pharmacological effects of ad-libitum electronic and combustible cigarette use among dual users.

ABSTRACT:

Background and aims

Relative pharmacological effects of e-cigarettes and cigarettes during 24 hours of ad-libitum use have not been described. In this study, 24-hour blood plasma nicotine concentrations and 48-hour subjective effects with use of cigarettes and e-cigarettes were measured among dual users.

Design

Two-arm within-subject cross-over design with preferred e-cigarette or cigarette ad-libitum use over 48 hours.

Setting

Hospital research ward in San Francisco, California, USA.

Participants

Thirty-six healthy dual users of e-cigarettes and cigarettes (n = 8, 25% females).

Measurements

Twenty-four-hour blood plasma nicotine and cotinine concentrations and 48-hour self-reported nicotine withdrawal symptoms and rewarding effects.

Findings

Anal

SUBMITTER: Harvanko AM 

PROVIDER: S-EPMC7255919 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature