Clinical validation of the Neonatal Infant Stressor Scale with preterm infant salivary cortisol.

ABSTRACT:

Background

Preterm infants face unique stress states in early life. Early-life stress has been associated with changes in cortisol reactivity and behavioral abnormalities later in childhood in non-preterm populations. The Neonatal Infant Stressor Scale (NISS) has been used to estimate infant stress in the neonatal intensive care unit (NICU) but has not been biomarker validated. The relationship between NISS scores and salivary cortisol is unknown. The aim of this study is to test the association between NISS scores and salivary cortisol in the NICU Hospital Exposures and Long-Term Health (NICU-HEALTH) preterm birth cohort.

Methods

Three hundred and eighty-six salivary cortisol specimens were collected from 125 NICU-HEALTH participants during the NICU hospitalization. NISS sc

SUBMITTER: Pourkaviani S 

PROVIDER: S-EPMC7255933 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature