A novel genomic region on chromosome 11 associated with fearfulness in dogs.

ABSTRACT: The complex phenotypic and genetic nature of anxieties hampers progress in unravelling their molecular etiologies. Dogs present extensive natural variation in fear and anxiety behaviour and could advance the understanding of the molecular background of behaviour due to their unique breeding history and genetic architecture. As dogs live as part of human families under constant care and monitoring, information from their behaviour and experiences are easily available. Here we have studied the genetic background of fearfulness in the Great Dane breed. Dogs were scored and categorised into cases and controls based on the results of the validated owner-completed behavioural survey. A genome-wide association study in a cohort of 124 dogs with and without socialisation as a covariate revealed a

SUBMITTER: Sarviaho R 

PROVIDER: S-EPMC7256038 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature