Clostridioides difficile infections in the intensive care unit: a monocentric cohort study.

ABSTRACT:

Introduction

Patient-level data from Clostridioides difficile infections (CDI) treated in an intensive care setting is limited, despite the growing medical and financial burden of CDI.

Methods

We retrospectively analyzed data from 100 medical intensive care unit patients at the University Hospital Cologne with respect to demography, diagnostics, severity scores, treatment, and outcome. To analyze factors influencing response to treatment and death, a backward-stepwise multiple logistic regression model was applied.

Results

Patients had significant comorbidities including 26% being immunocompromised. The mean Charlson Comorbidity Index was 6.3 (10-year survival rate of 2.25%). At the time of diagnosis, the APACHE II was 17.4±6.3 (predicted mortality rate of 25%), and t

SUBMITTER: Aguilar RC 

PROVIDER: S-EPMC7256083 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature