Effects of statin therapy and exercise on postprandial triglycerides in overweight individuals with hypercholesterolaemia.

ABSTRACT:

Aims

To determine the effects of statins on postprandial lipaemia (PPL) and to study if exercise could enhance statin actions.

Methods

Ten hypercholesteraemic (blood cholesterol 204 ± 36 mg dL^-1 ; low-density lipoprotein-cholesterol 129 ± 32 36 mg dL^-1 ) overweight (body mass index 30 ± 4 kg m^-2 ), metabolic syndrome individuals chronically medicated with statins (>6 months) underwent 5-hour PPL tests in 4 occasions in a randomized order: (i) substituting their habitual statin medication by placebo for 96 hours (PLAC trial); (ii) taking their habitual statin medicine (STA trial); (iii) placebo combined with a bout of intense aerobic exercise (EXER+PLAC trial); and (iv) combining exercise and statin medicine (EXER+STA trial).

Results

Be

SUBMITTER: Mora-Rodriguez R 

PROVIDER: S-EPMC7256119 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature