Monocyte count and the risk for acute exacerbation of fibrosing interstitial lung disease: A retrospective cohort study.

ABSTRACT: Recent studies have suggested that an increased peripheral monocyte count predicts a poor outcome in fibrosing interstitial lung disease (ILD). However, the association between an increased monocyte count and acute exacerbations (AEs) of fibrosing ILD remains to be elucidated. Our retrospective cohort study aimed to assess the impact of peripheral monocyte count on AEs of fibrosing ILD. We analyzed the electronic medical records of 122 consecutive patients with fibrosing ILD and no prior history of an AE, who were treated with anti-fibrotic agents from August 2015 to December 2018. We determined their peripheral monocyte counts at anti-fibrotic agent initiation and performed univariate and multivariate Cox regression analyses of time-to-first AE after anti-fibrotic agent initiation to asse

SUBMITTER: Kawamura K 

PROVIDER: S-EPMC7256331 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature