The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis.

ABSTRACT:

Purpose

To provide a comprehensive account of the association of five Lymphotoxin-α (LTA) gene polymorphisms (rs1041981, rs2229094, rs2239704, rs746868, rs909253) with susceptibility to cancer.

Methods

A literature search for eligible candidate gene studies published before 28 February 2020 was conducted in the PubMed, Medline, Google Scholar and Web of Science. The following combinations of main keywords were used: (LTA OR Lymphotoxin alpha OR TNF-β OR tumor necrosis factor-beta) AND (polymorphism OR mutation OR variation OR SNP OR genotype) AND (cancer OR tumor OR neoplasm OR malignancy OR carcinoma OR adenocarcinoma). Potential sources of heterogeneity were sought out via subgroup and sensitivity analysis, and publication bias were estimated.

Results

Overall, a tot

SUBMITTER: Li J 

PROVIDER: S-EPMC7256675 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature