Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study.

ABSTRACT:

Background

In women with singleton pregnancies, maternal adaptation is considered a stress test for later life cardiovascular disease. The aim of this study was to assess maternal adaptation in women with twin pregnancies compared to women carrying singletons during and after pregnancy.

Methods

This was a population based prospective cohort study of 91 women with twin pregnancies and 8107 women carrying singletons. The association of twin pregnancy and maternal adaptation was examined using regression analyses. In pregnancy, we measured soluble fms-like tyrosine kinase-1 (sFLT-1), placental growth (PGF) factor, systolic (SBP) and diastolic blood pressure (DBP), and the occurrence of pre-eclampsia (PE). After pregnancy, measurements were obtained on SBP and DBP, cardiac funct

SUBMITTER: Adank MC 

PROVIDER: S-EPMC7257120 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature