MethGET: web-based bioinformatics software for correlating genome-wide DNA methylation and gene expression.

ABSTRACT:

Background

DNA methylation is a major epigenetic modification involved in regulating gene expression. The effects of DNA methylation on gene expression differ by genomic location and vary across kingdoms, species and environmental conditions. To identify the functional regulatory roles of DNA methylation, the correlation between DNA methylation changes and alterations in gene expression is crucial. With the advance of next-generation sequencing, genome-wide methylation and gene expression profiling have become feasible. Current bioinformatics tools for investigating such correlation are designed to the assessment of DNA methylation at CG sites. The correlation of non-CG methylation and gene expression is very limited. Some bioinformatics databases allow correlation analysis, but th

SUBMITTER: Teng CS 

PROVIDER: S-EPMC7257144 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature