Whole blood transcriptomic investigation identifies long non-coding RNAs as regulators in sepsis.

ABSTRACT:

Background

Sepsis is a fatal disease referring to the presence of a known or strongly suspected infection coupled with systemic and uncontrolled immune activation causing multiple organ failure. However, current knowledge of the role of lncRNAs in sepsis is still extremely limited.

Methods

We performed an in silico investigation of the gene coexpression pattern for the patients response to all-cause sepsis in consecutive intensive care unit (ICU) admissions. Sepsis coexpression gene modules were identified using WGCNA and enrichment analysis. lncRNAs were determined as sepsis biomarkers based on the interactions among lncRNAs and the identified modules.

Results

Twenty-three sepsis modules, including both differentially expressed modules and prognostic modules, were id

SUBMITTER: Cheng L 

PROVIDER: S-EPMC7257169 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature