Chronic vagus nerve stimulation for drug-resistant epilepsy may influence fasting blood glucose concentration.

ABSTRACT:

Background

Cervical vagus nerve stimulation (VNS) has been widely accepted as adjunctive therapy for drug-resistant epilepsy and major depression. Its effects on glycemic control in humans were however poorly understood. The aim of our study was to investigate the potential effects of VNS on fasting blood glucose (FBG) in patients with drug-resistant epilepsy.

Methods

Patients with drug-resistant epilepsy who had received VNS implants at the same hospital were retrospectively studied. Effects on FBG, weight, body mass index and blood pressure were evaluated at 4, 8 and 12 months of follow-up.

Results

32 subjects (11 females/21 males, 19 ± 9 years, body mass index 22.2 ± 4.0 kg/m²) completed 12-month follow-up. At the 4 months, there were no significant chan

SUBMITTER: Liu H 

PROVIDER: S-EPMC7257242 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature