Dietary Choline Intake During Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study

ABSTRACT: Abstract

Objectives

Choline-metabolizing genetic variation may interact with choline intake on fetal programming and pregnancy outcome. This case-control study aims to explore the association of maternal choline consumption and phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphism rs7946 with incident preterm birth.

Methods

165 Chinese Han women with preterm delivery and 165 Chinese Han women with term delivery were recruited in Shanghai, China. Dietary choline intake during pregnancy was assessed using a validated food frequency questionnaire. Additionally, DNA samples were genotyped for PEMT rs7946 (G5465A) by a real-time polymerase chain reaction method with plasma homocysteine (Hcy) levels measured by an enzymatic cycling method. Odds ratio (OR) and 95

SUBMITTER: Zhu J 

PROVIDER: S-EPMC7257329 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature