Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.

ABSTRACT: This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer. The circular RNA expression microarray "GSE101123" related to breast cancer was downloaded from the Gene Expression Omnibus database. The differentially expressed circular RNAs between tumor and normal samples were screened using Limma package. The targeted microRNAs of the differentially expressed circular RNAs and the targeted messenger RNAs of the microRNAs were predicted using miRanda and miRWalk, respectively, and a circular RNAs-microRNAs-messenger RNAs network was constructed. Then, functional enrichment analysis, protein-protein interaction network construction, and drug-gene interaction analysis were conducted for the

SUBMITTER: Peng Z 

PROVIDER: S-EPMC7257864 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature