Safety and function of a new pre-vascularized bioartificial pancreas in an allogeneic rat model.

ABSTRACT: Cell encapsulation could overcome limitations of free islets transplantation but is currently limited by inefficient cells immune protection and hypoxia. As a response to these challenges, we tested in vitro and in vivo the safety and efficacy of a new macroencapsulation device named MailPan^®. Membranes of MailPan^® device were tested in vitro in static conditions. Its bio-integration and level of oxygenation was assessed after implantation in non-diabetic rats. Immune protection properties were also assessed in rat with injection in the device of allogeneic islets with incompatible Major Histocompatibility Complex. Finally, function was assessed in diabetic rats with a Beta cell line injected in MailPan^®. In vitro, membranes of the device showed high permea

SUBMITTER: Magisson J 

PROVIDER: S-EPMC7257875 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature