Gene-Environment Interactions Between PPARG2 Variant and Lifestyle Factors in Relation to Cancer RIsk: A Systematic Review

ABSTRACT: Abstract

Objectives

A genetic variant in peroxisome proliferator-activated receptor-gamma (PPARG2 Pro12Ala; rs1801282) has been linked to both carcinogenesis and lifestyle factors such as energy balance and fat intake and identified as modifiers of risk in several different cancers. However, to date, no systematic review has been conducted. We conducted a systematic literature review to summarize the current evidence on whether associations between lifestyle factors and risk of cancer are modified by the PPARG2 Pro12Ala variant.

Methods

We conducted a systematic literature review of studies published before July 2019 using the PubMed database. We included observational studies that: 1) included diet, anthropometrics and physical activity as lifestyle factors; 2) had the r

SUBMITTER: Tran L 

PROVIDER: S-EPMC7258078 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature