Proinflammatory Effects in Ex Vivo Human Lung Tissue of Respirable Smoke Extracts from Indoor Cooking in Nepal.

ABSTRACT: Rationale: Exposure to biomass smoke is believed to increase the risk of developing chronic obstructive pulmonary disease. However, little is known about the mechanisms underlying responses to biomass smoke in human lungs.Objectives: This study had two objectives: first, to quantify "real-life" exposures to particulate matter <2 μm in diameter (PM_2.5) and carbon monoxide (CO) measured during cooking on stoves in rural areas of Nepal in different geographical settings; and second, to assess the effect of biomass smoke extracts on inflammatory responses in ex vivo human lung tissue.Methods: Personal exposures to PM_2.5 and indoor near-stove CO concentrations were measured during cooking on a range of stoves in 103 households in 4 different Nep

SUBMITTER: Kc B 

PROVIDER: S-EPMC7258415 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature