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Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice.


ABSTRACT: Classical bovine spongiform encephalopathy (BSE) is the only zoonotic prion disease described to date. Although the zoonotic potential of atypical BSE prions have been partially studied, an extensive analysis is still needed. We conducted a systematic study by inoculating atypical BSE isolates from different countries in Europe into transgenic mice overexpressing human prion protein (PrP): TgMet129, TgMet/Val129, and TgVal129. L-type BSE showed a higher zoonotic potential in TgMet129 mice than classical BSE, whereas Val129-PrP variant was a strong molecular protector against L-type BSE prions, even in heterozygosis. H-type BSE could not be transmitted to any of the mice. We also adapted 1 H- and 1 L-type BSE isolate to sheep-PrP transgenic mice and inoculated them into human-PrP transgenic mice. Atypical BSE prions showed a modification in their zoonotic ability after adaptation to sheep-PrP producing agents able to infect TgMet129 and TgVal129, bearing features that make them indistinguishable of sporadic Creutzfeldt-Jakob disease prions.

SUBMITTER: Marin-Moreno A 

PROVIDER: S-EPMC7258450 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice.

Marín-Moreno Alba A   Huor Alvina A   Espinosa Juan Carlos JC   Douet Jean Yves JY   Aguilar-Calvo Patricia P   Aron Naima N   Píquer Juan J   Lugan Sévérine S   Lorenzo Patricia P   Tillier Cecile C   Cassard Hervé H   Andreoletti Olivier O   Torres Juan María JM  

Emerging infectious diseases 20200601 6


Classical bovine spongiform encephalopathy (BSE) is the only zoonotic prion disease described to date. Although the zoonotic potential of atypical BSE prions have been partially studied, an extensive analysis is still needed. We conducted a systematic study by inoculating atypical BSE isolates from different countries in Europe into transgenic mice overexpressing human prion protein (PrP): TgMet<sub>129</sub>, TgMet/Val<sub>129</sub>, and TgVal<sub>129</sub>. L-type BSE showed a higher zoonotic  ...[more]

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