Ontology highlight
ABSTRACT:
SUBMITTER: Marin-Moreno A
PROVIDER: S-EPMC7258450 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Marín-Moreno Alba A Huor Alvina A Espinosa Juan Carlos JC Douet Jean Yves JY Aguilar-Calvo Patricia P Aron Naima N Píquer Juan J Lugan Sévérine S Lorenzo Patricia P Tillier Cecile C Cassard Hervé H Andreoletti Olivier O Torres Juan María JM
Emerging infectious diseases 20200601 6
Classical bovine spongiform encephalopathy (BSE) is the only zoonotic prion disease described to date. Although the zoonotic potential of atypical BSE prions have been partially studied, an extensive analysis is still needed. We conducted a systematic study by inoculating atypical BSE isolates from different countries in Europe into transgenic mice overexpressing human prion protein (PrP): TgMet<sub>129</sub>, TgMet/Val<sub>129</sub>, and TgVal<sub>129</sub>. L-type BSE showed a higher zoonotic ...[more]