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Genomic Epidemiology of 2015-2016 Zika Virus Outbreak in Cape Verde.

ABSTRACT: During 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations.

SUBMITTER: Faye O 

PROVIDER: S-EPMC7258482 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Genomic Epidemiology of 2015-2016 Zika Virus Outbreak in Cape Verde.

Faye Oumar O   de Lourdes Monteiro Maria M   Vrancken Bram B   Prot Matthieu M   Lequime Sebastian S   Diarra Maryam M   Ndiaye Oumar O   Valdez Tomas T   Tavarez Sandra S   Ramos Jessica J   da Veiga Leal Silvânia S   Pires Cecilio C   Moreira Antonio A   Tavares Maria Filomena MF   Fernandes Linete L   Barreto Jorge Noel JN   do Céu Teixeira Maria M   de Lima Mendonça Maria da Luz MDL   Gomes Carolina Cardoso da Silva Leite CCDSL   Castellon Mariano Salazar MS   Ma Laurence L   Lemoine Frédéric F   Gámbaro-Roglia Fabiana F   Delaune Déborah D   Fall Gamou G   Fall Ibrahima Socé IS   Diop Mamadou M   Sakuntabhai Anavaj A   Loucoubar Cheikh C   Lemey Philippe P   Holmes Edward C EC   Faye Ousmane O   Sall Amadou Alpha AA   Simon-Loriere Etienne E  

Emerging infectious diseases 20200601 6

During 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic ev  ...[more]

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