Effects of host genetic variations on response to, susceptibility and severity of respiratory infections.

ABSTRACT: The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a global crisis, necessitating the identification of genetic factors that modulate the risk of disorder or its severity. The current data about the role of genetic risk factors in determination of rate of SARS-CoV-2 infection in each ethnic group and the severity of disorder is limited. Moreover, several confounding parameters such as the number of tests performed in each country, the structure of the population especially the age distribution, the presence of risk factors for respiratory disorders such as smoking and other environmental factors might be involved in the variability in disease course or prevalence of infection among different ethnic groups. However, assessment of the role of

SUBMITTER: Ghafouri-Fard S 

PROVIDER: S-EPMC7258806 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature