Comprehensive analysis reveals a metabolic ten-gene signature in hepatocellular carcinoma.

ABSTRACT:

Background

Due to the complicated molecular and cellular heterogeneity in hepatocellular carcinoma (HCC), the morbidity and mortality still remains high level in the world. However, the number of novel metabolic biomarkers and prognostic models could be applied to predict the survival of HCC patients is still small. In this study, we constructed a metabolic gene signature by systematically analyzing the data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and International Cancer Genome Consortium (ICGC).

Methods

Differentially expressed genes (DEGs) between tumors and paired non-tumor samples of 50 patients from TCGA dataset were calculated for subsequent analysis. Univariate cox proportional hazard regression and LASSO analysis were performed to construc

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC7258935 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature