Darunavir Pharmacokinetics With an Increased Dose During Pregnancy.

ABSTRACT:

Background

This study aims to evaluate the pharmacokinetics of an increased dose of darunavir (800 mg twice daily) with 100 mg ritonavir during pregnancy and postpartum.

Methods

Darunavir (DRV) and ritonavir (RTV; r) intensive pharmacokinetic evaluations were performed at steady state during the second and third trimesters of pregnancy (DRV/r 800/100 mg bid) and 2-3 weeks postpartum (DRV/r 600/100 mg twice daily). Plasma concentrations of darunavir and ritonavir were measured using high-performance liquid chromatography. Target darunavir area under the concentration time curve (AUC) was >70% (43.6 μg × h/mL) of median AUC (62.3 μg × h/mL) in nonpregnant adults on twice daily darunavir-ritonavir 600/100 mg.

Results

Twenty-four women were included in the analysis. Darun

SUBMITTER: Eke AC 

PROVIDER: S-EPMC7258985 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature