Multi-Omic Regulation of the PAM50 Gene Signature in Breast Cancer Molecular Subtypes.

ABSTRACT: Breast cancer is a disease that exhibits heterogeneity that goes from the genomic to the clinical levels. This heterogeneity is thought to be captured (at least partially) by the so-called breast cancer molecular subtypes. These molecular subtypes were initially defined based on the unsupervised clustering of gene expression and its correlate with histological, morphological, phenotypic and clinical features already known. Later, a 50-gene signature, PAM50, was defined in order to identify the biological subtype of a given sample within the clinical setting. The PAM50 signature was obtained by the use of unsupervised statistical methods, and therefore no limitation was set on the biological relevance (or lack of) of the selected genes beyond its predictive capacity. An open question that r

SUBMITTER: Ochoa S 

PROVIDER: S-EPMC7259379 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature