Sevoflurane depletes macrophages from the melanoma microenvironment.

ABSTRACT:

Background

With more than 18 million annual new cases, cancer belongs to the major challenges of modern healthcare. Surgical resection of solid tumours under general anaesthesia is the prime therapy. Different aspects of anaesthesia are under discussion to independently influence the long-term outcome of cancer patients. Most recently, the commonly used volatile anaesthetics like sevoflurane have entered the spotlight, as retrospective studies suggest a detrimental outcome in certain cancer aetiologies with sparse mechanistic understanding. Our objective was to investigate this concept in a murine melanoma model, herein comparing the consequence of inhalative and injection anesthesia on tumour composition and growth.

Methods

We used a murine model of malignant melanoma in ma

SUBMITTER: Sztwiertnia I 

PROVIDER: S-EPMC7259700 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature