Cbl-Associated Protein CAP contributes to correct formation and robust function of the Drosophila heart tube.

ABSTRACT: The formation of a tube-like structure is a basic step in the making of functional hearts in vertebrates and invertebrates and therefore, its understanding provides important information on heart development and function. In Drosophila, the cardiac tube originates from two bilateral rows of dorsally migrating cells. On meeting at the dorsal midline, coordinated changes in cell shape and adhesive properties transform the two sheets of cells into a linear tube. ECM and transmembrane proteins linked to the cytoskeleton play an important role during these dynamic processes. Here we characterize the requirement of Cbl-Associated Protein (CAP) in Drosophila heart formation. In embryos, CAP is expressed in late migrating cardioblasts and is located preferentially at their luminal and abluminal pe

SUBMITTER: Jammrath J 

PROVIDER: S-EPMC7259718 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature