The prevalence of occult HBV infection in immunized children with HBsAg-positive parents: a hospital-based analysis.

ABSTRACT:

Background and object

The risk of occult HBV infection (OBI) in children whose mothers are HBV carriers has received more widespread attention, but there were few reports to focus on the children with HBsAg-positive parents. In this study, we aimed to investigate the prevalence of OBI in immunized children with HBsAg-positive parents.

Methods

HBV-vaccinated Chinese hospitalized children with HBsAg-positive parents were analyzed in our investigation. Eligible subjects were tested using a standard nested PCR for all HBV genes, and analyzed by direct sequencing.

Results

There were 327 HBsAg-negative children included in the study out of about 9800 involved HBV-vaccinated hospitalized children. The positive rate of OBI was 3.1% (10/327) in the eligible children and 14.1%

SUBMITTER: Zhuge S 

PROVIDER: S-EPMC7259741 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature