Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations.

ABSTRACT:

Background

A considerable challenge in quantification of the antimalarial piperaquine in plasma is carryover of analyte signal between assays. Current intensive pharmacokinetic studies often rely on the merging of venous and capillary sampling. Drug levels in capillary plasma may be different from those in venous plasma, Thus, correlation between capillary and venous drug levels needs to be established.

Methods

Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was used to develop the method. Piperaquine was measured in 205 pairs of capillary and venous plasma samples collected simultaneously at ≥24hr post dose in children, pregnant women and non-pregnant women receiving dihydroartemisinin-piperaquine as malaria chemoprevention. Standard three-dose regime

SUBMITTER: Mwebaza N 

PROVIDER: S-EPMC7259774 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature