Retrospective cohort study to characterise the blood pressure response to spironolactone in patients with apparent therapy-resistant hypertension using electronic medical record data.

ABSTRACT:

Objective

Identify blood pressure (BP) response to spironolactone in patients with apparent therapy-resistant hypertension (aTRH) using electronic medical records (EMRs) in order to estimate response in a real-world clinical setting.

Design

Developed an algorithm to determine BP and electrolyte response to spironolactone for use in a retrospective cohort study.

Setting

An academic medical centre in Nashville, Tennessee.

Population

Patients with aTRH prescribed spironolactone.

Main outcome measures

Baseline BP and BP response, determined as the change in mean systolic BP (SBP) and diastolic BP (DBP) following spironolactone initiation. Additional response measures were serum sodium, potassium and creatinine, estimated glomerular filtration rate, haemoglob

SUBMITTER: Shuey M 

PROVIDER: S-EPMC7259833 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature