Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments.

ABSTRACT: Mycobacterium tuberculosis (Mtb) infection results in a spectrum of clinical and histopathologic manifestations. It has been proposed that the environmental and immune pressures associated with different contexts of infection have different consequences for the associated bacterial populations, affecting drug susceptibility and the emergence of resistance. However, there is little concrete evidence for this model. We prospectively collected sputum samples from 18 newly diagnosed and treatment-naïve patients with tuberculosis and sequenced 795 colony-derived Mtb isolates. Mutant accumulation rates varied considerably between different bacilli isolated from the same individual, and where high rates of mutation were observed, the mutational spectrum was consistent with re

SUBMITTER: Liu Q 

PROVIDER: S-EPMC7259932 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature