Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults.

ABSTRACT: Age-related episodic memory decline is characterized by striking heterogeneity across individuals. Hippocampal pattern completion is a fundamental process supporting episodic memory. Yet, the degree to which this mechanism is impaired with age, and contributes to variability in episodic memory, remains unclear. We combine univariate and multivariate analyses of fMRI data from a large cohort of cognitively normal older adults (N=100) to measure hippocampal activity and cortical reinstatement during retrieval of trial-unique associations. Trial-wise analyses revealed that (a) hippocampal activity scaled with reinstatement strength, (b) cortical reinstatement partially mediated the relationship between hippocampal activity and associative retrieval, (c) older age weakened cortical reinstateme

SUBMITTER: Trelle AN 

PROVIDER: S-EPMC7259949 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature