ER-luminal [Ca²⁺] regulation of InsP₃ receptor gating mediated by an ER-luminal peripheral Ca²⁺-binding protein.

ABSTRACT: Modulating cytoplasmic Ca²⁺ concentration ([Ca²⁺]_i) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP₃R) Ca²⁺-release channels is a universal signaling pathway that regulates numerous cell-physiological processes. Whereas much is known regarding regulation of InsP₃R activity by cytoplasmic ligands and processes, its regulation by ER-luminal Ca²⁺ concentration ([Ca²⁺]_ER) is poorly understood and controversial. We discovered that the InsP₃R is regulated by a peripheral membrane-associated ER-luminal protein that strongly inhibits the channel in the presence of high, physiological [Ca²⁺]_ER. The widely-expressed Ca²⁺-bi

SUBMITTER: Vais H 

PROVIDER: S-EPMC7259957 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature