Ontology highlight
ABSTRACT:
SUBMITTER: Gjyrezi A
PROVIDER: S-EPMC7259995 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Gjyrezi Ada A Xie Fang F Voznesensky Olga O Khanna Prateek P Calagua Carla C Bai Yang Y Kung Justin J Wu Jim J Corey Eva E Montgomery Bruce B Mace Sandrine S Gianolio Diego A DA Bubley Glenn J GJ Balk Steven P SP Giannakakou Paraskevi P Bhatt Rupal S RS
The Journal of clinical investigation 20200601 6
Despite widespread use of taxanes, mechanisms of action and resistance in vivo remain to be established, and there is no way of predicting who will respond to therapy. This study examined prostate cancer (PCa) xenografts and patient samples to identify in vivo mechanisms of taxane action and resistance. Docetaxel drug-target engagement was assessed by confocal anti-tubulin immunofluorescence to quantify microtubule bundling in interphase cells and aberrant mitoses. Tumor biopsies from metastatic ...[more]