Ontology highlight
ABSTRACT:
SUBMITTER: Cheng X
PROVIDER: S-EPMC7259999 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20200601 6
In patients with HBV and HCV coinfection, HBV reactivation leading to severe hepatitis has been reported with the use of direct-acting antivirals (DAAs) to treat HCV infection. Here we studied the molecular mechanisms behind this viral interaction. In coinfected cell culture and humanized mice, HBV replication was suppressed by HCV coinfection. In vitro, HBV suppression was attenuated when interferon (IFN) signaling was blocked. In vivo, HBV viremia, after initial suppression by HCV superinfecti ...[more]