Ontology highlight
ABSTRACT:
SUBMITTER: Kober-Hasslacher M
PROVIDER: S-EPMC7260018 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20200601 6
Single-nucleotide polymorphisms and locus amplification link the NF-κB transcription factor c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the functional consequences of enhanced c-Rel levels remain enigmatic. Here, we overexpressed c-Rel specifically in mouse B cells from BAC-transgenic gene loci and demonstrate that c-Rel protein levels linearly dictated expansion of germinal center B (GCB) cells and isotype-switched plasma cells. c-Rel expression in B cells of ...[more]