Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface.
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ABSTRACT:
SUBMITTER: Li R
PROVIDER: S-EPMC7260039 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface.
Li Rongbo R Li Xiaoping X Hagood James J Zhu Min-Sheng MS Sun Xin X
The Journal of clinical investigation 20200601 6
A majority (~95%) of the gas-exchange surface area is generated through septa formation during alveologenesis. Disruption of this process leads to alveolar simplification and bronchopulmonary dysplasia (BPD), a prevalent disorder in premature infants. Although several models have been proposed, the mechanism of septa formation remains under debate. Here we show that inactivation of myosin light chain kinase (MLCK), a key factor required for myofibroblast contraction, disrupted septa formation, s ...[more]
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