Sulphur doped carbon dots enhance photodynamic therapy via PI3K/Akt signalling pathway.

ABSTRACT:

Objectives

Photodynamic therapy (PDT) is a promising approach for cancer treatment, and the underlying signalling pathway changes has been carried out for studying the PDT mechanisms, but is majorly limited to organic photosensitizers (PSs). For the emerging nano-PSs typically possessing higher ¹ O₂ quantum yield, few mechanistic studies were carried out, which limited their further applications in clinical therapeutics. PI3K/Akt signalling pathway, a most frequently activated signalling network in cancers, could promote cancer cell survival, but was seldom reported in previous PDT studies mediated by nano-PSs.

Materials and methods

Sulphur doped carbon dots (S-CDs) was prepared via a hydrothermal synthetic route and was characterized by transmission el

SUBMITTER: Li Y 

PROVIDER: S-EPMC7260068 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature