Integration of nano- and biotechnology for beta-cell and islet transplantation in type-1 diabetes treatment.

ABSTRACT: Regenerative medicine using human or porcine β-cells or islets has an excellent potential to become a clinically relevant method for the treatment of type-1 diabetes. High-resolution imaging of the function and faith of transplanted porcine pancreatic islets and human stem cell-derived beta cells in large animals and patients for testing advanced therapy medicinal products (ATMPs) is a currently unmet need for pre-clinical/clinical trials. The iNanoBIT EU H2020 project is developing novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole-body distribution of the cellular transplants in a porcine diabetes model with excellent translational potential to humans. We develop and validate the application o

SUBMITTER: Dinnyes A 

PROVIDER: S-EPMC7260069 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature