Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study.

ABSTRACT: It remains unclear whether the increased risk of new-onset type 2 diabetes (T2D) seen in statin users is due to low LDL-C concentrations, or due to the statin-induced proportional change in LDL-C. In addition, genetic instruments have not been proposed before to examine whether liability to T2D might cause greater proportional statin-induced LDL-C lowering. Using summary-level statistics from the Genomic Investigation of Statin Therapy (GIST, n_max = 40,914) and DIAGRAM (n_max = 159,208) consortia, we found a positive genetic correlation between LDL-C statin response and T2D using LD score regression (r_genetic = 0.36, s.e. = 0.13). However, mendelian randomization analyses did not provide support for statin response having a causal effect on T2D risk (OR 1.00

SUBMITTER: Smit RAJ 

PROVIDER: S-EPMC7260089 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature