A week-long outpatient induction onto XR-naltrexone in patients with opioid use disorder.

ABSTRACT:

Background

Extended-release (XR) naltrexone can prevent relapse to opioid use disorder following detoxification. However, one of the barriers to initiating XR-naltrexone is the recommendation for a 7-10-day period of abstinence from opioids prior to the first dose.

Objectives

The current study evaluated the feasibility of an XR-naltrexone induction protocol that can be implemented over 1 week in the outpatient clinic.

Methods

Participants (N = 44) were seen in the clinic daily. On Day 1, after abstaining from opioids for at least 12 h, they received buprenorphine 6-8 mg. Adjunctive medications (clonidine, clonazepam, zolpidem, trazodone, and prochlorperazine) were dispensed on Days 2-5, while ascending oral doses of naltrexone were given on Days 3-5 starting with 1 mg

SUBMITTER: Sibai M 

PROVIDER: S-EPMC7260104 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature