Relationships between plasma lipidomic profiles and brown adipose tissue density in humans.

ABSTRACT:

Background/objectives

The thermogenic function of brown adipose tissue (BAT) is generally activated in winter and tightly regulated through various metabolic processes. However, the mechanisms mediating these changes have not been elucidated in humans. Here, we investigated the relationships between BAT density (BAT-d) and lipid metabolites in plasma from men and women in the winter and summer.

Subjects/methods

In total, 92 plasma samples were obtained from 23 men and 23 women, aged 21-55 years, on two different occasions (summer and winter). Lipid metabolites were comprehensively quantified using liquid chromatography-time-of-flight-mass spectrometry. BAT-d was evaluated by measuring total hemoglobin concentrations in the supraclavicular region using near-infrared time-reso

SUBMITTER: Fuse S 

PROVIDER: S-EPMC7260127 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature