The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABA_A receptors.

ABSTRACT: Increasing evidence indicates that guidance molecules used during development for cellular and axonal navigation also play roles in synapse maturation and homeostasis. In C. elegans the netrin receptor UNC-40/DCC controls the growth of dendritic-like muscle cell extensions towards motoneurons and is required to recruit type A GABA receptors (GABA_ARs) at inhibitory neuromuscular junctions. Here we show that activation of UNC-40 assembles an intracellular synaptic scaffold by physically interacting with FRM-3, a FERM protein orthologous to FARP1/2. FRM-3 then recruits LIN-2, the ortholog of CASK, that binds the synaptic adhesion molecule NLG-1/Neuroligin and physically connects GABA_ARs to prepositioned NLG-1 clusters. These processes are orchestrated by the synaptic org

SUBMITTER: Zhou X 

PROVIDER: S-EPMC7260190 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature