Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice.

ABSTRACT: In the past decade, the high morbidity and mortality of atherosclerotic disease have been prevalent worldwide. High-fat food consumption has been suggested to be an overarching factor for atherosclerosis incidence. This study aims to investigate the effects of kefir peptides on high-fat diet (HFD)-induced atherosclerosis in apolipoprotein E knockout (ApoE^-/-) mice. 7-week old male ApoE^-/- and normal C57BL/6 mice were randomly divided into five groups (n = 8). Atherosclerotic lesion development in ApoE^-/- mice was established after fed the HFD for 12 weeks compared to standard chow diet (SCD)-fed C57BL/6 and ApoE^-/- control groups. Kefir peptides oral administration significantly improved atherosclerotic lesion development by protecting against en

SUBMITTER: Tung MC 

PROVIDER: S-EPMC7260220 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature