Use of static and dynamic [18F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression.

ABSTRACT: BACKGROUND:Static [18F]-F-DOPA PET images are currently used for identifying patients with glioma recurrence/progression after treatment, although the additional diagnostic value of dynamic parameters remains unknown in this setting. The aim of this study was to evaluate the performances of static and dynamic [18F]-F-DOPA PET parameters for detecting patients with glioma recurrence/progression as well as assess further relationships with patient outcome. METHODS:Fifty-one consecutive patients who underwent an [18F]-F-DOPA PET for a suspected glioma recurrence/progression at post-resection MRI, were retrospectively included. Static parameters, including mean and maximum tumor-to-normal-brain (TBR) ratios, tumor-to-striatum (TSR) ratios, and metabolic tumor volume (MTV), as well as dynamic p

SUBMITTER: Zaragori T 

PROVIDER: S-EPMC7260331 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature