Modulation of inter-organ signalling in obese mice by spontaneous physical activity during mammary cancer development.

ABSTRACT: Accumulative evidence links breast cancer development to excess weight and obesity. During obesity, dysregulations of adipose tissue induce an increase in pro-inflammatory adipokine secretions, such as leptin and oestrogen secretions. Furthermore, a raise in oxidative stress, along with a decrease in antioxidant capacity, induces and maintains chronic inflammation, which creates a permissive environment for cancer development. Physical activity is recommended as a non-pharmacological therapy in both obese and cancer situations. Physical activity is associated with a moderation of acute inflammation, higher antioxidant defences and adipokine regulation, linked to a decrease of tumour-cell proliferation. However, the biological mechanisms underlying the relationship between oxidative stress,

SUBMITTER: Le Guennec D 

PROVIDER: S-EPMC7260359 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature