Recombinant spider silk protein eADF4(C16)-RGD coatings are suitable for cardiac tissue engineering.

ABSTRACT: Cardiac tissue engineering is a promising approach to treat cardiovascular diseases, which are a major socio-economic burden worldwide. An optimal material for cardiac tissue engineering, allowing cardiomyocyte attachment and exhibiting proper immunocompatibility, biocompatibility and mechanical characteristics, has not yet emerged. An additional challenge is to develop a fabrication method that enables the generation of proper hierarchical structures and constructs with a high density of cardiomyocytes for optimal contractility. Thus, there is a focus on identifying suitable materials for cardiac tissue engineering. Here, we investigated the interaction of neonatal rat heart cells with engineered spider silk protein (eADF4(C16)) tagged with the tripeptide arginyl-glycyl-aspartic acid cell

SUBMITTER: Kramer JPM 

PROVIDER: S-EPMC7260369 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature