Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients.

ABSTRACT:

Background

Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients.

Methods

Levels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagnosis at three Spanish hospitals.

Results

There were 100 patients with infection, 95 with sepsis and 57 with septic shock. Seven biomarkers indicating endothelial dysfunction (mid-regional proadrenomedullin (MR-ProADM), syndecan 1, thrombomodulin, angiopoietin 2, endothelial cell-specific molec

SUBMITTER: Martin-Fernandez M 

PROVIDER: S-EPMC7260414 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature