Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment.

ABSTRACT: COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes only mild symptoms in the majority of the cases, while immunologic complications such as macrophage activation syndrome also known as secondary hemophagocytic lymphohistiocytosis, resulting in cytokine storm syndrome and acute respiratory distress syndrome, may also occur in some patients. According to current literature, impairment of SARS-CoV-2 clearance due to genetic and viral features, lower levels of interferons, increased neutrophil extracellular traps, and increased pyroptosis and probable other unknown mechanisms create a background for severe disease course complicated by macrophage activation syndrome and cytokine storm. Various genetic mutations may also constitute a risk factor for severe di

SUBMITTER: Soy M 

PROVIDER: S-EPMC7260446 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature